Clearing and Masking Agents in Pretargeting Strategies
Markus Staudt, Matthias M. Herth
Abstract
'Pretargeting' led to increased target-to-background ratios of nanomedicines in short timeframes. However, clearing or masking agents are needed to reach the full potential of pretargeted approaches. This review gives an overview of clearing and masking agents employed in pretargeting strategies in both preclinical and clinical settings and discusses how these agents work.
Topics & Concepts
PretargetingClearingMasking (illustration)Masking agentMedicineComputer scienceMedical physicsChemistryImmunologyArtAntibodyChromatographyVisual artsEconomicsMonoclonal antibodyRadioimmunotherapyFinanceNanoparticle-Based Drug DeliveryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery