OTUD6B-AS1 Inhibits Viability, Migration, and Invasion of Thyroid Carcinoma by Targeting miR-183-5p and miR-21
Zhuolu Wang, Fada Xia, Tiecheng Feng, Bo Jiang, Wenlong Wang, Xinying Li
Abstract
Background: The long noncoding RNA (lncRNA) functions as a regulator of initiation, progression, and metastasis of thyroid carcinomas. lncRNA OTUD6B antisense RNA 1 (OTUD6B-AS1) is a tumor-suppressive noncoding RNA in clear cell renal cell carcinoma. The role of OTUD6B-AS1 in thyroid carcinomas has not been reported yet. We aim to investigate the expression and biological functions of OTUD6B-AS1 in thyroid carcinomas.
Topics & Concepts
Thyroid carcinomaCancer researchViability assayThyroidMetastasisCarcinomamicroRNALong non-coding RNALuciferaseBiologyCellMedicinePathologyCell cultureRNACancerTransfectionInternal medicineEndocrinologyGeneGeneticsBiochemistryCancer-related molecular mechanisms researchMicroRNA in disease regulationCircular RNAs in diseases