Cobalt induces neurodegenerative damages through impairing autophagic flux by activating hypoxia-inducible factor-1α triggered ROS overproduction
Jianping Tang, Yanjun Li, Xu Liu, Guangxia Yu, Fuli Zheng, Zhenkun Guo, Yating Zhang, Wenya Shao, Siying Wu, Huangyuan Li
Topics & Concepts
AutophagyNeurodegenerationNeurotoxicityReactive oxygen speciesCell biologyPI3K/AKT/mTOR pathwayToxicantProtein kinase BBiologyChemistryBiochemistryPhosphorylationSignal transductionMedicineApoptosisToxicityInternal medicineOrganic chemistryDiseaseAutophagy in Disease and TherapyHeme Oxygenase-1 and Carbon MonoxideIntracerebral and Subarachnoid Hemorrhage Research