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Incorporating Pharmacological Target-Mediated Drug Disposition (TMDD) in a Whole-Body Physiologically Based Pharmacokinetic (PBPK) Model of Linagliptin in Rat and Scale-up to Human

Nan Wu, Guohua An

2020The AAPS Journal10 citationsDOI

Topics & Concepts

PharmacokineticsLinagliptinPhysiologically based pharmacokinetic modellingChemistryPharmacologyDrugDissociation constantEndocrinologyBiochemistryReceptorBiologyType 2 diabetesDiabetes mellitusDiabetes Treatment and ManagementNeuropeptides and Animal PhysiologyReceptor Mechanisms and Signaling
Incorporating Pharmacological Target-Mediated Drug Disposition (TMDD) in a Whole-Body Physiologically Based Pharmacokinetic (PBPK) Model of Linagliptin in Rat and Scale-up to Human | Litcius