Synthesis of novel benzothiazole derivatives and investigation of their enzyme inhibitory effects against Alzheimer's disease
Şevval Karaca, Derya Osmani̇ye, Begüm Nurpelin Sağlık, Serkan Levent, Sinem Ilgın, Yusuf Özkay, Ahmet Çağrı Karaburun, Zafer Asım Kaplancıklı, Nalan Gündoğdu-Karaburun
Abstract
studies also support the obtained biological activity findings. Compound 4f provided strong interactions with the active site of both enzymes. In particular, the interaction of compound 4f with flavin adenine dinucleotide (FAD) in the MAO-B enzyme active site is a promising and exciting finding.
Topics & Concepts
BenzothiazoleInhibitory postsynaptic potentialChemistryEnzymeEnzyme inhibitionAlzheimer's diseaseDiseasePharmacologyBiochemistryCombinatorial chemistryStereochemistryNeuroscienceMedicineInternal medicineBiologyCholinesterase and Neurodegenerative DiseasesChemical synthesis and alkaloidsComputational Drug Discovery Methods