Pressure overload generates a cardiac-specific profile of inflammatory mediators
Matthew T. O’Brien, Catalin F. Baicu, An O. Van Laer, Yuhua Zhang, Lindsay T. McDonald, Amanda C. LaRue, Michael R. Zile, Amy D. Bradshaw
Abstract
Myocardial fibrosis and the resultant increases in myocardial stiffness represent pivotal consequences of chronic pressure overload (PO). In this study, cytokine profiles produced in a murine model of cardiac fibrosis induced by PO were compared with those produced in response to silica-induced lung fibrosis. A unique profile of cardiac tissue-specific and plasma-derived factors generated in response to PO are reported.
Topics & Concepts
Pressure overloadFibrosisCardiac fibrosisMedicineCardiologyMyocardial fibrosisInflammatory responseInternal medicineCytokineInflammationHeart failureCardiac hypertrophyCardiac Fibrosis and RemodelingCardiovascular Function and Risk FactorsOccupational and environmental lung diseases