Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1/TLR4/NF-κB pathway
Jie Wu, Ziwen Hao, Ying Wang, Dongying Yan, Jia Meng, Honglin Ma
Topics & Concepts
NeuroinflammationMicrogliaMorris water navigation taskMelatoninNeuroprotectionSirtuin 1ChemistryNeurotoxicityTLR4Hippocampal formationPharmacologyCREBNF-κBEndocrinologyInternal medicineMedicineSignal transductionInflammationToxicityBiochemistryDownregulation and upregulationTranscription factorGeneNeuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsTryptophan and brain disorders