Synthesis of polysubstituted azetidines <i>via</i> cascade trifluoromethylation/cyclization of <i>N</i>-allyl ynamides
Genlai Zhou, Jingwen Su, Tianbo Shang, Xiaojuan Wang, Yihui Bai, Zheliang Yuan, Gangguo Zhu
Abstract
A cascade trifluoromethylation/cyclization of <italic>N</italic>-allyl sulfonylynamides is developed, providing a direct access to azetidine-fused tricyclic compounds at room temperature.
Topics & Concepts
TrifluoromethylationChemistryCascadeTricyclicCombinatorial chemistryMedicinal chemistryOrganic chemistryTrifluoromethylChromatographyAlkylFluorine in Organic ChemistryCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions