Scratching the Surface: NECTIN-4 as a Surrogate for Enfortumab Vedotin Resistance
David H. Aggen, Carissa Chu, Jonathan E. Rosenberg
Abstract
Clinical data with enfortumab vedotin (EV) suggest that most bladder cancers overexpress NECTIN-4. A recent article shows that NECTIN-4 membranous expression changes with progression to metastatic disease and that low NECTIN-4 expression in metastatic biopsies is potentially associated with EV resistance. These data argue for incorporation of NECTIN-4 expression into future biomarker strategies. See related article by Klümper et al., p. 1496.
Topics & Concepts
NectinBiomarkerMedicineOncologyInternal medicineCancer researchPathologyBiologyCell adhesionCellGeneticsBladder and Urothelial Cancer TreatmentsUrinary and Genital Oncology StudiesInfectious Disease Case Reports and Treatments