Dendritic hybrid materials comprising polyhedral oligomeric silsesquioxane (POSS) and hyperbranched polyglycerol for effective antifungal drug delivery and therapy in systemic candidiasis
Mahboobeh Jafari, Samira Sadat Abolmaali, Sedigheh Borandeh, Haniyeh Najafi, Zahra Zareshahrabadi, Omid Koohi‐Hosseinabadi, Negar Azarpira, Kamiar Zomorodian, Ali Mohammad Tamaddon
Abstract
infections in an experimental model of systemic candidiasis and can effectively reduce or eliminate AMB liver and kidney tissue injuries. Thanks to their safety, biocompatibility, and unique therapeutic properties, the developed POSS-polyglycerol dendrimers could be viable nanostructures for the delivery of poorly soluble drugs like AMB.
Topics & Concepts
SilsesquioxaneDendrimerAmphotericin BBiocompatibilityDrug deliveryDrugDrug carrierChemistryMaterials sciencePharmacologyMicrobiologyAntifungalMedicinePolymer chemistryOrganic chemistryBiologyPolymerDendrimers and Hyperbranched PolymersAntimicrobial agents and applicationsSynthesis and properties of polymers