Protease-Responsive Peptide-Conjugated Mitochondrial-Targeting AIEgens for Selective Imaging and Inhibition of SARS-CoV-2-Infected Cells
Yong Cheng, Alex E. Clark, Jiajing Zhou, Tengyu He, Yi Li, Raina M. Borum, Matthew N. Creyer, Ming Xu, Zhicheng Jin, Jingcheng Zhou, Wonjun Yim, Zhuohong Wu, Pavla Fajtová, Anthony J. O’Donoghue, Aaron F. Carlin, Jesse V. Jokerst
Abstract
, we verified that the cleavage of PSGMR yielded gradual aggregation with bright fluorescence and enhanced cytotoxicity to induce mitochondrial interference of the infected cells. This strategy may have value for selective detection and treatment of SARS-CoV-2-infected cells.
Topics & Concepts
ProteasePeptideAggregation-induced emissionCytotoxicityTransfectionConjugated systemChemistryCell biologyBiologyIn vitroEnzymeBiochemistryFluorescenceGenePolymerPhysicsQuantum mechanicsOrganic chemistryNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniquesLuminescence and Fluorescent Materials