An Integrated Janus Patch with Asymmetric Tissue Adhesion for Enhanced Postoperative Adhesion Prevention
Xiaofan Tan, Xing Hu, Xiaoyu Pan, Wenjiao Xie, D.S. Li, Youyong Yuan, Jun Wang
Abstract
High Resolution Image Download MS PowerPoint Slide Postoperative abdominal adhesion is a prevalent issue with high incidence rates, often resulting in complications such as bowel obstruction and infertility. Currently, poly(lactic acid) (PLA)-based anti-adhesion membranes are extensively used for the prevention of abdominal adhesions. However, these membranes necessitate suturing, which increases the risk of secondary injury. In this study, we present a Janus patch with asymmetric adhesion properties designed to prevent postoperative abdominal adhesions. The patch consists of two functional layers: an adhesive layer made of a poly(lactic acid- co -ethylethylene phosphate) copolymer, which achieves tissue adhesion via hydrophilicity, hydrogen bonding, and electrostatic interactions, and a non-adhesive layer composed of electrospun PLA membrane. We characterized various properties of the Janus patch, including its morphology, adhesive properties, and biocompatibility. Adhesive properties tests revealed that the adhesive layer of the Janus patch demonstrated superior adhesive capabilities on various tissues compared to the non-adhesive PLA layer. In vivo experiments indicated that the asymmetric adhesive properties of the Janus patch effectively prevent postoperative abdominal adhesions. This work highlights a promising approach for addressing the challenges associated with adhesion prevention and secondary injuries, paving the way for safer and more effective postoperative care.