Importance of Osmolarity and Oxygen Tension for Cartilage Tissue Engineering
Stefan Sieber, M. Michaelis, Hans Gühring, S. Lindemann, Anne Gigout
Abstract
the chondrocytes-matrix constructs were found to more closely resemble native cartilage regarding the matrix-to-cell ratio. In conclusion, this study clearly demonstrates the benefit of using physiological oxygen tension and osmolarity in cartilage tissue engineering with the combination of both showing the strongest benefit on the chondrocyte phenotype.
Topics & Concepts
Oxygen tensionOsmotic concentrationChondrocyteCartilageTissue engineeringCell biologyMatrix (chemical analysis)ChemistryExtracellular matrixAggrecanAndrologyBiologyOxygenAnatomyBiochemistryArticular cartilageOsteoarthritisBiomedical engineeringPathologyMedicineAlternative medicineOrganic chemistryChromatographyOsteoarthritis Treatment and MechanismsAngiogenesis and VEGF in CancerKnee injuries and reconstruction techniques