Redox double-switch cancer theranostics through Pt(<scp>iv</scp>) functionalised manganese dioxide nanostructures
Beatriz Brito, María Ruggiero, Thomas W. Price, Milene Costa da Silva, Núria Genicio, Annah J. Wilson, Olga Tyurina, Veronika Rosecker, Thomas R. Eykyn, Manuel Bañobre‐López, Graeme J. Stasiuk, Juan Gallo
Abstract
A new redox-responsive double-switch cancer theranostic was developed based on Mn nanostructures and a Pt prodrug. The ability of these probes to respond to altered redox states was validated in 2/3D cell models and in a preclinical mouse model.
Topics & Concepts
ProdrugAscorbic acidIn vivoCisplatinChemistryRedoxCytotoxicityIn vitroA549 cellManganeseNanoparticleCancer cellBiophysicsCancer researchNanotechnologyMaterials scienceCancerBiochemistryChemotherapyOrganic chemistryMedicineBiologySurgeryFood scienceInternal medicineBiotechnologyNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryNanocluster Synthesis and Applications