Synergistic enhancement of the emergency treatment effect of organophosphate poisoning by a supramolecular strategy
Junyi Chen, Yadan Zhang, Yao Chai, Zhao Meng, Yahan Zhang, Longming Chen, Dongqin Quan, Yongan Wang, Qingbin Meng, Chunju Li
Abstract
studies revealed that complexation by CP6A serves to increase the AChE reactivation efficiency of PAM. The formation of the PAM/CP6A complex contributed to enhance in a statistically significant way the ability of PAM not only to relieve symptoms of seizures but also to improve the survival ratio in paraoxon-poisoned model rats. These favorable findings are attributed to synergistic effects that PAM reactivates AChE to hydrolyze ACh and excess ACh is encapsulated in the cavity of CP6A to relieve cholinergic crisis symptoms.
Topics & Concepts
OrganophosphateOrganophosphate poisoningSupramolecular chemistryChemistryEmergency treatmentNanotechnologyMedicineMaterials scienceMedical emergencyOrganic chemistryMoleculePesticideBiologyAgronomyPesticide Exposure and ToxicityChemical Reaction MechanismsSynthesis and Characterization of Heterocyclic Compounds