Merging Photocatalytic Doubly‐Decarboxylative C<sub>sp</sub><sup>2</sup>−C<sub>sp</sub><sup>2</sup> Cross‐Coupling for Stereo‐Selective (<i>E</i>)‐<i>α</i>,<i>β</i>‐Unsaturated Ketones Synthesis
Subal Mondal, Siba P. Midya, Soumya Mondal, Suman Das, Pradyut Ghosh
Abstract
cross coupling reaction is disclosed. Merging iridium and palladium photocatalysis manifested carbon-carbon bonds in a tandem dual-radical pathway. Present catalytic platform efficiently cross-coupled α, β-unsaturated acids and α-keto acids to afford a variety of α, β-unsaturated ketones with excellent (E)-selectivity and functional group tolerance. Mechanistically, photocatalyst implicated through reductive quenching cycle whereas cross coupling proceeded over one electron oxidative pallado-cycle.
Topics & Concepts
PhotocatalysisQuenching (fluorescence)CatalysisChemistryIridiumCatalytic cyclePhotochemistryKetoneMedicinal chemistryOrganic chemistryPhysicsFluorescenceQuantum mechanicsRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques