The Chemical Inhibitors of Endocytosis: From Mechanisms to Potential Clinical Applications
Olga Klaudia Szewczyk-Roszczenko, Piotr Roszczenko, Anna Shmakova, Nataliya Finiuk, Serhii Holota, Roman Lesyk, Anna Bielawska, Yegor Vassetzky, Krzysztof Bielawski
Abstract
Endocytosis is one of the major ways cells communicate with their environment. This process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic transformation. Here, we review the approaches to inhibit endocytosis, discuss chemical inhibitors of this process, and discuss potential clinical applications of the endocytosis inhibitors.
Topics & Concepts
EndocytosisReceptor-mediated endocytosisCell biologyChemistryBiologyBiochemistryCellCaveolin-1 and cellular processesCellular transport and secretionGlycosylation and Glycoproteins Research