Carbapenem resistant Campylobacter jejuni bacteremia in a Bruton’s X-linked agammaglobulinemia patient
Ran Zhuo, Ramee Younes, Kevin W. Ward, Shangxin Yang
Abstract
Immunocompromised patients are prone to recurrent Campylobacter infections. We report a case of recurrent multi-drug resistant Campylobactor jejuni bloodstream infections in a Bruton's X-linked agammaglobulinemia patient with prolonged ertapenem treatment. The isolate from the fifth recurrence developed carbapenem resistance, which is associated with mutations in a porin gene porA, and promoter changes and duplication of chromosomal blaOXA-61 gene. Combination therapy using cefepime and doxycycline (later switched to moxifloxacin) cleared the infection.
Topics & Concepts
ErtapenemCampylobacter jejuniBacteremiaCefepimeMedicineMicrobiologyMoxifloxacinCarbapenemVirologyAntibioticsBiologyImipenemAntibiotic resistanceBacteriaGeneticsSalmonella and Campylobacter epidemiologyInfections and bacterial resistancePlant Pathogenic Bacteria Studies