Copper‐Catalyzed Difluoroalkylation‐Thiolation of Alkenes Promoted by Na<sub>2</sub>S<sub>2</sub>O<sub>5</sub>
Bao Gao, Yingjie Ni, Xiaojun Liu, Tao Jiang, Qian Yan, Ruiting Yang, Xiuli Zhang
Abstract
Abstract A novel and convenient protocol for the difluoroalkylation‐thiolation of alkenes catalyzed by Cu/Na 2 S 2 O 5 system has been developed. This reaction was carried out using readily available starting materials under mild conditions, wherein the C−C and C−S bonds simultaneously were constructed smoothly. The reaction features broad substrate scope of alkenes and disulfides, good functional group tolerance, and good to excellent yields with high selectivity.
Topics & Concepts
ChemistryCatalysisSubstrate (aquarium)SelectivityCombinatorial chemistryCopperFunctional groupReaction conditionsScope (computer science)Organic chemistryComputer scienceGeologyProgramming languageOceanographyPolymerFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesCarbon dioxide utilization in catalysis