Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer’s Disease
Michele Rossi, Michela Freschi, Luciana de Camargo Nascente, Alessandra Salerno, Sarah de Melo Viana Teixeira, Florian Nachon, Fabien Chantegreil, Ondřej Soukup, Lukáš Prchal, Marco Malaguti, Christian Bergamini, Manuela Bartolini, Cristina Angeloni, Silvana Hrelia, Luiz Antônio Soares Romeiro, María Laura Bolognesi
Abstract
(already at 0.01 μM), confirming the design rationale.
Topics & Concepts
TacrineAcetylcholinesteraseChemistryButyrylcholinesteraseAchéNeuroprotectionCholinesteraseDrugPharmacologyToxicityDrug discoveryEnzymeBiochemistryOrganic chemistryMedicineComputational Drug Discovery MethodsCholinesterase and Neurodegenerative DiseasesNuclear Receptors and Signaling