Cell-intrinsic differences between human airway epithelial cells from children and adults
Elizabeth Maughan, Robert E. Hynds, Adam Pennycuick, Ersilia Nigro, Kate H.C. Gowers, Céline Denais, Sandra Gómez‐López, Kyren A. Lazarus, Jessica C. Orr, David R. Pearce, Sarah E. Clarke, Dani Do Hyang Lee, Maximillian Woodall, Tereza Masonou, Katie‐Marie Case, Vitor H. Teixeira, Benjamin Hartley, Richard Hewitt, Chadwan Al Yaghchi, Gurpreet Sandhu, Martin Birchall, Christopher O’Callaghan, Claire M. Smith, Paolo De Coppi, Colin R. Butler, Sam M. Janes
Abstract
growth, and outcompeted adult cells in a direct competitive proliferation assay. Our results demonstrate cell-intrinsic differences between airway epithelial cells from children and adults in both homeostatic and proliferative states.
Topics & Concepts
AirwayCellMedicineChemistryCell biologyBiologyGeneticsAnesthesiaNeonatal Respiratory Health ResearchAsthma and respiratory diseasesRespiratory Support and Mechanisms