Immunoediting in acute myeloid leukemia: Reappraising T cell exhaustion and the aberrant antigen processing machinery in leukemogenesis
Ching‐Yun Wang, Shiuan-Chen Lin, Kao-Jung Chang, Han-Ping Cheong, Sin-Rong Wu, Cheng-Hao Lee, Ming-Wei Chuang, Shih‐Hwa Chiou, Chih‐Hung Hsu, Po‐Shen Ko
Abstract
T cell exhaustion is a hotspot in recent clinical oncology studies, but its pathophysiology has yet to be elucidated in AML. In this review, we summarize high-quality original studies encompassing the phenotypic and genomic characteristics of T cell exhaustion events in the leukemia progression, emphasize the surface immuno-peptidome that dynamically tunes the fate of T cells to function or dysfunction states, and revisit the biochemical and biophysical properties of type 1 MHC antigen processing mechanism (APM) that pivots in the phenomenon of leukemia antigen dampening.
Topics & Concepts
ImmunoeditingMyeloid leukemiaAntigenLeukemiaImmunologyMyeloidMedicineBiologyCancer researchImmunotherapyImmune systemImmune Cell Function and InteractionCAR-T cell therapy researchT-cell and B-cell Immunology