Is epigenome editing non-inheritable? Implications for ethics and the regulation of human applications
Mitsuru Sasaki‐Honda, Kyoko Akatsuka, Tsutomu Sawai
Abstract
Epigenome editing offers ethical advantages with non-inheritable gene expression control. However, concerns arise regarding potential transgenerational effects in humans. Ethical and regulatory evaluation is crucial, considering recent advancements and enhanced understanding of transgenerational epigenetics in both mammals and humans.
Topics & Concepts
EpigenomeTransgenerational epigeneticsBiologyEpigeneticsGenome editingComputational biologyGeneticsEngineering ethicsGeneGene expressionDNA methylationGenomeEngineeringCRISPR and Genetic EngineeringEpigenetics and DNA MethylationPluripotent Stem Cells Research