Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
Mushtaq Ahmad Nengroo, Austin T. Klein, Heather S. Carr, Olivia Vidal-Cruchez, Umakant Sahu, Daniel J. McGrail, Nidhi Sahni, Niklas B Thompson, Peter Faull, Peng Gao, John M. Asara, Hardik Shah, Marc L. Mendillo, Issam Ben‐Sahra
Topics & Concepts
BiologySerine hydroxymethyltransferasePurinePurine metabolismNucleotide salvageBiochemistryDe novo synthesisNucleotideMetabolic pathwayMitochondrionMetabolismSerineCell biologyGlycolysisPurine nucleoside phosphorylaseCitric acid cycleEnzymeCell cyclePurine analogueAdenosine triphosphateCellPentose phosphate pathwaySignal transductionBiochemical and Molecular ResearchSirtuins and Resveratrol in MedicineFolate and B Vitamins Research