BCL2 inhibitor ABT-199 and BCL2L1 inhibitor WEHI-539 coordinately promote NOXA-mediated degradation of MCL1 in human leukemia cells
Jing‐Ting Chiou, Yuan‐Chin Lee, Liangjun Wang, Long‐Sen Chang
Topics & Concepts
MCL1CytotoxicityU937 cellDownregulation and upregulationChemistryCytotoxic T cellCell culturePharmacologyCell biologyApoptosisBiologyBiochemistryIn vitroGeneGeneticsUbiquitin and proteasome pathwaysCell death mechanisms and regulationinterferon and immune responses