New chlorophenolic glycoside from <i>Curculigo orchioides</i> and their activities on 5α-reductase
Xue-Li Deng, Ruirong Zheng, Zhu‐Zhen Han, Lihua Gu, Zhengtao Wang
Abstract
Two new chlorophenolic glucosides curculigines P (1) and Q (2), together with seven known compounds (3–9), were isolated from the dried rhizomes of Curculigo orchioides. Their structures were determined by spectroscopic methods including 1 D, 2 D NMR and MS. All the isolated compounds were evaluated on 5α-reductase activity by a HaCaT-based bioassay. Compounds 1–9 showed varying degrees of inhibiting activity against 5α-reductase, while compound 1 indicated the most potent inhibitory effect.
Topics & Concepts
RhizomeHaCaTStereochemistryChemistryGlycosideBioassayReductaseEnzymeBiochemistryBotanyIn vitroBiologyGeneticsNatural product bioactivities and synthesisPhytochemistry and Biological ActivitiesPlant biochemistry and biosynthesis