Visible-light-induced selective defluoroalkylations of polyfluoroarenes with alcohols
Wengang Xu, Qi Shao, Congjian Xia, Qiao Zhang, Yadi Xu, Ying‐Guo Liu, Mingbo Wu
Abstract
A green and feasible synthetic protocol for α-polyfluoroarylalcohols was developed with polyfluoroarenes and alcohols via Lewis acid-assisted synergistic photoredox and hydrogen-atom transfer catalysis under batch or flow conditions.
Topics & Concepts
RegioselectivityChemistryPhotoredox catalysisLewis acids and basesCombinatorial chemistryAlkylHydrogen atomOrganic chemistryCatalysisPhotocatalysisFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques