Combinational Deletions of MGF360-9L and MGF505-7R Attenuated Highly Virulent African Swine Fever Virus and Conferred Protection against Homologous Challenge
Mingyang Ding, Wen Dang, Huanan Liu, Fan Xu, Huaguo Huang, Yongjie Sunkang, Tao Li, Jingjing Pei, Xiangtao Liu, Yong Zhang, Haixue Zheng
Abstract
Currently, the deficiency in commercially available vaccines or therapeutic options against African swine fever constitutes a matter of major concern in the swine industry globally. Here, we report the design and construction of a recombinant ASFV mutant harboring combinational deletions of interferon inhibitors MGF360-9L and MGF505-7R based on a genotype II ASFV CN/GS/2018 strain currently circulating in China.
Topics & Concepts
BiologyVirologyVirulenceHomologous chromosomeAfrican swine fever virusVirusHomologous recombinationGeneticsGeneAnimal Disease Management and EpidemiologyVector-Borne Animal DiseasesViral gastroenteritis research and epidemiology