<scp>Metal‐Free</scp> Arylsulfonyl Radical Triggered Cascade Cyclization of <scp>Phenyl‐Linked</scp> 1,<scp>6‐Enynes</scp>: Synthesis of 2,<scp>3‐Dihydro‐1<i>H</i></scp>‐indenes and 10<i>a</i>,<scp>11‐Dihydro‐10<i>H</i></scp>‐benzo[<i>b</i>]fluorines
Lin‐Ping Hu, De‐Run Zhang, Xiao‐Hong Huang, Fenglin Liu, Xia Li, Ming‐Yu Teng, Guoli Huang
Abstract
Comprehensive Summary Aryl sulfonyl radical triggered cascade cyclization of phenyl‐linked 1,6‐enynes for the synthesis of biologically important indenes containing alkenyl C—X bonds and 10 a ,11‐dihydro‐10 H ‐benzo[ b ]fluorines is presented. In these radical cascade processes, three new chemical bonds, including C—S, C—C, and C—X bonds, and three C—C bonds are formed in one step. The method is attractive and valuable due to its metal‐free, mild reaction conditions, broad substrate scope and good functional group tolerance.
Topics & Concepts
ChemistrySulfonylCascadeSubstrate (aquarium)ArylStereochemistryCombinatorial chemistryRadical cyclizationReaction conditionsMedicinal chemistryFunctional groupOrganic chemistryCatalysisAlkylPolymerOceanographyGeologyChromatographyCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions