Human cytomegalovirus expands a CD8 <sup>+</sup> T cell population with loss of <i>BCL11B</i> expression and gain of NK cell identity
Rosa Sottile, M. Kazim Panjwani, Colleen M. Lau, Anthony F. Daniyan, Kento Tanaka, Juliet N. Barker, Renier J. Brentjens, Joseph C. Sun, Jean-Benoît Le Luduec, Katharine C. Hsu
Abstract
T cells represent a lymphocyte population that resides at the boundary between innate and adaptive immunity, presenting an attractive alternative for cellular therapy, including CAR T cell–based therapies.
Topics & Concepts
Cytotoxic T cellBiologyCell biologyPopulationCD8Interleukin 21ImmunologyT cellAcquired immune systemImmune systemMedicineGeneticsEnvironmental healthIn vitroImmune Cell Function and InteractionCAR-T cell therapy researchT-cell and B-cell Immunology