Photoredox/Nickel Dual Catalysis-Enabled Cross-Dehydrogenative C–H Amination of Indoles with Unactivated Amine
Jie Gao, Xian‐Chen He, Yanling Liu, Zhipeng Ye, Jianping Guan, Kai Chen, Hao‐Yue Xiang, Hua Yang
Abstract
Herein, a direct cross-dehydrogenative C-H amination of indoles has been successfully achieved, enabled by the merger of photocatalysis with nickel catalysis. This developed process does not require stoichiometric oxidants and prefunctionalization of amine partners, providing a concise platform for C-N bond formation. Moreover, the synthetic practicality of this transformation was well revealed by its high step- and atom-economy, high reaction efficiency, and broad functional group tolerance.
Topics & Concepts
ChemistryAminationAtom economyCatalysisAmine gas treatingFunctional groupCombinatorial chemistryPhotocatalysisStoichiometryNickelSynergistic catalysisPhotochemistryOrganic chemistryPolymerCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques