Men and women display distinct extracellular vesicle biomarker signatures in response to military operational stress
William R. Conkright, Meaghan E. Beckner, Amrita Sahu, Qi Mi, Zachary Clemens, Mita Lovalekar, Shawn D. Flanagan, Brian J. Martin, Fabio Ferrarelli, Fabrisia Ambrosio, Bradley C. Nindl
Abstract
Sex is understudied in EV research, and most studies limit EV analysis to single stress conditions such as exercise. Multistress conditions consisting of physical exertion and sleep and caloric restriction are common in real-world settings. We demonstrate that physical exertion results in sex-specific EV signatures and that EV profiles vary according to single versus multistress conditions. Our data highlight important biological and ecological characteristics that should be considered in EV research.
Topics & Concepts
ExertionBiomarkerPhysical stressExtracellular vesiclePerceived exertionHeat stressStress (linguistics)BiologyEnvironmental healthPhysical medicine and rehabilitationMedicinePsychologyPhysical therapyHeart rateInternal medicineBlood pressureMicrovesiclesmicroRNAPhilosophyGeneLinguisticsBiochemistryAnimal scienceExtracellular vesicles in diseaseAir Quality and Health ImpactsHeat shock proteins research