Isolation and Pharmacological Characterization of Six Opioidergic <i>Picralima nitida</i> Alkaloids
Simone M. Creed, Anna M. Gutridge, Malaika D. Argade, Madeline Hennessy, J. Brent Friesen, Guido F. Pauli, Richard M. van Rijn, Andrew P. Riley
Abstract
alkaloids and the traditional use of akuamma seeds as analgesics. Nevertheless, their opioid-preferring activity does suggest the akuamma alkaloids provide distinct scaffolds from which novel opioids with unique pharmacologic properties and therapeutic utility can be developed.
Topics & Concepts
OpioidergicIsolation (microbiology)ChemistryTraditional medicineBiologyMedicineBiochemistryAntagonistBioinformaticsReceptor(+)-NaloxoneAlkaloids: synthesis and pharmacologyChemical synthesis and alkaloidsChromatography in Natural Products