BDNF rescues aging-associated internal anal sphincter dysfunction
Arjun Singh, Satish Rattan
2021American Journal of Physiology-Gastrointestinal and Liver Physiology49 citationsDOIOpen Access PDF
Abstract
These studies demonstrate that brain-derived neurotropic factor (BDNF) rescues the aging-associated internal anal sphincter (IAS) dysfunction, characterized by a decrease in IAS tone, and increase in non-adrenergic noncholinergic relaxation. We determined the effects of BDNF on the basal and GPCR (TXA 2 and ANG II)-stimulated IAS tone, and on NANC relaxation, before and after TrkB inhibitor K252a. BDNF may have an important role in the pathophysiology and therapeutic targeting of certain rectoanal motility disorders.
Topics & Concepts
RHOAInternal medicineTropomyosin receptor kinase BEndocrinologyInternal anal sphincterAgonistChemistryThromboxane A2MedicineReceptorNeurotrophic factorsSignal transductionBiochemistryRectumAnal canalPelvic floor disorders treatmentsAnorectal Disease Treatments and OutcomesEnhanced Recovery After Surgery