Revolutionizing cancer treatment: Nanotherapeutics targeting the tumor micro-environment
Deepak Chandra Joshi, Sonima Prasad, Vishal Bhati, Pravesh Kumar Sharma, Nirmal Joshi, Sumit Durgapal, Mayuri Bapu Chavan, Vishesh Kumar Maurya, Vetriselvan Subramaniyan, Keshav Raj Paudel, Madhu Gupta
Abstract
Precise targeting of the tumor micro-environment (TME) through nanotherapeutic innovations offers a transformative approach to cancer treatment. In order to increase the treatment efficacy, this review delves into the complex tactics for targeting different parts of the TME. Targeting the extracellular matrix, controlling acidosis and hypoxia, and preventing neovascularization by concentrating on pericytes and endothelial cells are important areas covered in this article. Strategies to stimulate anti-tumor immunity, regulate chronic inflammation, and restrict macrophage recruitment emphasize the immune system's participation. We have also highlighted the role of fibroblasts and exosomes linked to the cancer progression. The EPR effect, which is vital for cancer nanotherapeutics to work, and vascular pathophysiology are also included in the review. We examine how changes to the dynamics of pH inside the TME affect by nano-therapeutics. Additionally, the possibility of prodrug therapy within the TME, the use of controlled release mechanisms in nanocarriers to imitate metronomic therapy has been discussed. Lastly, the paper examines nanoparticle preference targeting as a potential strategy to improve treatment specificity and therapeutic efficacy in cancer management.