Trastuzumab potentiates doxorubicin-induced cardiotoxicity via activating the NLRP3 inflammasome in vivo and in vitro
Shanshan Wei, Wanjun Ma, Yuanying Yang, Taoli Sun, Chuanhao Jiang, Jian Liu, Bikui Zhang, Wenqun Li
Topics & Concepts
CardiotoxicityInflammasomeDoxorubicinPharmacologyOxidative stressApoptosisIn vivoTrastuzumabMedicineCancer researchInflammationChemistryBiologyEndocrinologyImmunologyInternal medicineCancerBiochemistryToxicityChemotherapyBiotechnologyBreast cancerChemotherapy-induced cardiotoxicity and mitigationPeptidase Inhibition and AnalysisDiamond and Carbon-based Materials Research