Inducible ablation of CD11c<sup>+</sup> cells to determine their role in skin wound repair
Zhi Li, Rebecca Lamb, Mark Coles, Clare L. Bennett, Carrie A. Ambler
Abstract
Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL-23-IL-22 axis that is required for wound healing.
Topics & Concepts
Wound healingCD11cWound closureSkin repairMyeloidImmunologyMedicineBiologyCancer researchGeneticsGenePhenotypeWound Healing and TreatmentsPressure Ulcer Prevention and ManagementDermatology and Skin Diseases