The dynamic dysregulated network identifies stage-specific markers during lung adenocarcinoma malignant progression and metastasis
Li Wang, Wangyang Liu, Kailai Liu, Lixia Wang, Xiangzhe Yin, Lin Bo, Haotian Xu, Shihua Lin, Ke Feng, Xinyu Zhou, Lin Lin, Meiting Fei, Caiyu Zhang, Shangwei Ning, Hongying Zhao
Abstract
) as prognostic markers in LUAD. Particularly, decreased expression of HLA-DRA, HLA-DRB1, HLA-DQB1, and HLA-DRB5 refer poor prognosis in LUAD by controlling antigen processing and presentation and T cell activation. Increased expression of PSMA3 and LYPLA1 refer poor prognosis by reprogramming fatty acid metabolism and RNA catabolic process. Our findings will help further understanding the pathobiology of brain metastases in LUAD.
Topics & Concepts
AdenocarcinomaBiologyMetastasisTumor progressionHuman leukocyte antigenReprogrammingCancer researchCancerGeneImmunologyAntigenGeneticsFerroptosis and cancer prognosisGlioma Diagnosis and TreatmentBrain Metastases and Treatment