Type II Fatty Acid Synthesis Pathway and Cyclopropane Ring Formation Are Dispensable during Enterococcus faecalis Systemic Infection
Constantin Hays, Clara Lambert, Sophie Brinster, Gilles Lamberet, Laurence du Merle, Karine Gloux, Alexandra Gruss, Claire Poyart, Agnès Fouet
Abstract
approaches. We conclude that neither the fatty acid synthesis pathway nor the cyclopropanation enzyme are suitable targets for E. faecalis antibiotic development.
Topics & Concepts
Enterococcus faecalisBiologyOperonMicrobiologyBiochemistryBacteriaVirulenceFatty acid synthesisFatty acidBacterial outer membraneGeneMutantEscherichia coliGeneticsAntimicrobial Resistance in StaphylococcusInfective Endocarditis Diagnosis and ManagementStreptococcal Infections and Treatments