Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development
Grennady Wirjanata, Jianqing Lin, Jerzy M. Dziekan, Abbas El Sahili, Zara Chung, Seth Tjia, Nur Elyza Binte Zulkifli, Josephine Boentoro, R. Tham, Lai Si Jia, Ka Diam Go, Han Yu, Anthony W. Partridge, David B. Olsen, Nayana Prabhu, Radoslaw M. Sobota, P. Nordlund, Julien Lescar, Zbynek Bozdech
Topics & Concepts
DruggabilityIsothermal titration calorimetryDrug developmentChemistryDrugMefloquinePlasmodium falciparumDrug discoveryComputational biologyBiologyMalariaBiochemistryPharmacologyGeneImmunologyMalaria Research and ControlPhenothiazines and Benzothiazines Synthesis and ActivitiesTrypanosoma species research and implications