A case study: Correlation of the nutrient composition in Chinese Hamster Ovary cultures with cell growth, antibody titre and quality attributes using multivariate analyses for guiding medium and feed optimization in early upstream process development
Marianne Saldanha, Ashutosh Shelar, Vaibhav Patil, Vishal G. Warke, Prajakta Dandekar, Ratnesh Jain
Topics & Concepts
Chinese hamster ovary cellFed-batch culturePartial least squares regressionNutrientBioprocessComposition (language)Multivariate statisticsBiologyTiterChemometricsCell cultureFood scienceBiochemistryChemistryMathematicsChromatographyAntibodyFermentationStatisticsImmunologyGeneticsPhilosophyEcologyPaleontologyLinguisticsViral Infectious Diseases and Gene Expression in InsectsProtein purification and stabilityFluid Dynamics and Mixing