Chitosan biguanide induced mitochondrial inhibition to amplify the efficacy of oxygen-sensitive tumor therapies
Zaigang Zhou, Chunjuan Zheng, Yu Liu, Wenjuan Luo, Hui Deng, Jianliang Shen
Topics & Concepts
BiguanideDoxorubicinPharmacologyReactive oxygen speciesMitochondrionCytotoxicityChemistryCancer researchHypoxia (environmental)Tumor hypoxiaIn vitroChemotherapyMedicineBiochemistryOxygenInternal medicineInsulinRadiation therapyMetforminOrganic chemistryNanoplatforms for cancer theranosticsCancer, Hypoxia, and MetabolismNanoparticle-Based Drug Delivery