Primary Amination of Ar<sub>2</sub>P(O)–H with (NH<sub>4</sub>)<sub>2</sub>CO<sub>3</sub> as an Ammonia Source under Simple and Mild Conditions and Its Extension to the Construction of Various P–N or P–O Bonds
Yushi Tan, Yaping Han, Yuecheng Zhang, Hong‐Yu Zhang, Jiquan Zhao, Shang‐Dong Yang
Abstract
A facile and efficient method for the synthesis of primary phosphinamides from Ar2P(O)–H reagents with stable and readily available ammonium carbonate as an ammonia source is disclosed herein for the first time. This ethyl bromoacetate-mediated primary amination proceeds smoothly under mild and simple conditions, without any metal catalyst or oxidant. Moreover, this method is also appropriate for the reaction of Ar2P(O)–H with a variety of amines, alcohols, and phenols to construct P–N or P–O bonds, with features of handy operation, good functional group tolerance, and broad substrate scope.
Topics & Concepts
AminationPrimary (astronomy)ReagentChemistryAmmoniaCatalysisSubstrate (aquarium)Functional groupAmmoniumCombinatorial chemistryAmmonium carbonateOrganic chemistryInorganic chemistryPolymerAstronomyOceanographyGeologyPhysicsAsymmetric Hydrogenation and CatalysisOrganophosphorus compounds synthesisChemical Synthesis and Reactions