Discovery of new 2-(3-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazole derivatives with potential analgesic and anti-inflammatory activities: In vitro, in vivo and in silico investigations
Eman R. Mohammed, Aliaa Abdelfatah, Abdalla R. Mohamed, Marianne Alphonse Mahrouse, Mohammad A. Mohammad
Topics & Concepts
ChemistryThiazoleIn vivoPyrazoleDocking (animal)StereochemistryCelecoxibHydrogen bondPotencySelectivityIn silicoPharmacologyIn vitroIC50BiochemistryMoleculeOrganic chemistryCatalysisBiotechnologyMedicineGeneBiologyNursingSynthesis and biological activityInflammatory mediators and NSAID effectsSynthesis and Biological Evaluation