Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors
Jolien De Neve, Thomas Barlow, Dirk Tourwé, Frédéric Bihel, Frédéric Simonin, Steven Ballet
Abstract
profiles showing the presence or the lack of specific side effects. This review comprises a comprehensive overview of biased ligands in addition to their bias factors at individual members of the opioid family of receptors, as well as bifunctional ligands.
Topics & Concepts
OpioidReceptorDrug discoveryPharmacologyComputational biologyNeuroscienceMedicineBiologyBioinformaticsInternal medicineReceptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyComputational Drug Discovery Methods