Reagent-free aerobic oxidative synthesis of amides from aldehydes and isothiocyanates
Jiang‐Sheng Li, Xin‐Yun Xie, Si Jiang, Panpan Yang, Zhiwei Li, Cui‐Hong Lu, Weidong Liu
Abstract
A reagent-free autoxidative reaction of aldehydes with isothiocyanates is developed to readily access amides, involving capture of carboxylic acids <italic>in situ </italic>generated from aldehydes by isothiocyanates as both coupling mediators and amine surrogates.
Topics & Concepts
ChemistryReagentAmine gas treatingAldehydeOrganic chemistryOxidative phosphorylationCombinatorial chemistryOxidative coupling of methaneCatalysisBiochemistryChemical Synthesis and AnalysisAdvanced Synthetic Organic ChemistryQuinazolinone synthesis and applications