Synthesis of Diversely Substituted Imidazolidines <i>via</i> [3+2] Cycloaddition of 1,3,5‐Triazinanes with Donor‐Acceptor Aziridines and Their Anti‐Tumor Activity
Zhichao Shi, Tingting Fan, Xun Zhang, Feng Zhan, Zhe Wang, Lei Zhao, Jin‐Shun Lin, Yuyang Jiang
Abstract
Abstract A Y(OTf) 3 ‐catalyzed [3+2] cycloaddition of 1,3,5‐triazinanes with donor‐acceptor aziridines has been developed, accessing diversely substituted imidazolidines high efficiency. Mechanistic investigations support the formation of imidazolidines through an S N 1‐like pathway. Furthermore, these imidazolidines exhibit promising anti‐tumor activity against a series of human cancer cell lines. magnified image
Topics & Concepts
ChemistryCycloadditionAcceptorStereochemistryCombinatorial chemistryStructural isomerCatalysisOrganic chemistryCondensed matter physicsPhysicsSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsClick Chemistry and Applications