Forty Years of Oxalobacter formigenes, a Gutsy Oxalate-Degrading Specialist
Steven L. Daniel, Luke Moradi, Henry J. Paiste, Kyle D. Wood, Dean G. Assimos, Ross P. Holmes, Lama Nazzal, Marguerite Hatch, John Knight
Abstract
Oxalobacter formigenes , a unique anaerobic bacterium that relies solely on oxalate for growth, is a key oxalate-degrading bacterium in the mammalian intestinal tract. Degradation of oxalate in the gut by O. formigenes plays a critical role in preventing renal toxicity in animals that feed on oxalate-rich plants.
Topics & Concepts
Calcium oxalateOxalateKidney stonesPrimary hyperoxaluriaMicrobiologyBiologyMedicineChemistryInternal medicineOrganic chemistryKidney Stones and Urolithiasis TreatmentsPorphyrin Metabolism and DisordersCassava research and cyanide