Intragenic Distribution of IS <i>6110</i> in Clinical Mycobacterium tuberculosis Strains: Bioinformatic Evidence for Gene Disruption Leading to Underdiagnosed Antibiotic Resistance
Rudy Antoine, Cyril Gaudin, Ruben C. Hartkoorn
Abstract
To help control the spread of drug-resistant tuberculosis and to guide treatment choices, it is important that rapid and accurate molecular diagnostic tools are used. Current molecular diagnostic tools detect the most common antibiotic-resistance-conferring mutations in the form of single nucleotide changes, small deletions, or insertions.
Topics & Concepts
Mycobacterium tuberculosisTuberculosisBiologyGeneticsAntibiotic resistanceEthionamideGeneAntibioticsMedicineRifampicinEthambutolPathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisBacteriophages and microbial interactions