circGNAQ, a circular RNA enriched in vascular endothelium, inhibits endothelial cell senescence and atherosclerosis progression
Weipeng Wu, Meng‐yuan Zhou, Dongliang Liu, Xue Min, Tong Shao, Ziyang Xu, Xia Jing, Meng‐yun Cai, Shun Xu, Xin Liang, Miaohua Mo, Xinguang Liu, Xing‐dong Xiong
Abstract
studies showed that circGNAQ overexpression in the endothelium inhibited endothelial cell senescence and atherosclerosis progression. These results suggest that circGNAQ plays critical roles in endothelial cell senescence and consequently the pathogenesis of atherosclerosis, implying that the management of circGNAQ provides a potential therapeutic approach for limiting the progression of atherosclerosis.
Topics & Concepts
SenescenceEndothelial stem cellBiologyCell biologyEndotheliumAngiogenesisCellVascular endothelial growth factor BGene silencingEndogenyEndothelial dysfunctionVascular endothelial growth factor ACancer researchVascular endothelial growth factorGeneBiochemistryGeneticsIn vitroEndocrinologyVEGF receptorsCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research